I have installed MSFS in D:\Microsoft Flight Simulator and I have no other additional libraries other than the usual Community directory.
I have also tried to unistall Paderborn Scenery and I still get the same error when start ASUpdater.
Again, contact either Nvidia or Microsoft to solve this. There is nothing Aerosoft can do.
Recommendation from my side:
uninstall the driver completely and try a fresh install or install the ODE version.
In general: ther is no need to always install the latest driver, other then it fixes issues you have seen, or you have a specific hardware that is only supported with the latest driver