I haven't ever had this issue until recently. Flying KDFW-KTYR, entering the ILS 04 arrival had my instruments and sound lock up (note, this was after a previous flight from KLRD-KDFW). The aircraft still functioned as a barebones aircraft, e.g. I could select flaps and was able to keep thrust and land. The second flight from KTYR-KDFW went uneventful (after a restart), then I continued on from KDFW-KSWO, in which when selecting the RNAV 36, it locked up again. For my two instances, which have never happened before, it was on my second flight of that session. I've flown up to four or five legs before without this happening but for some reason it has been more recently. It may be coincidental that these are happening on my second leg but it seems it may be a little more than that. On these flights I loaded the flight from a simbrief generated .flp file. I'm also thinking it may be the fact that I have deleted most of the waypoints to manually input them as the departures I ran were not actual 'preloaded' departures but points that needed to manually input to fly. These departures were the TEX1 and the GAR1.
UPDATE: I made a video of me recreating the issue I was specifically having using the same KDFW-KTYR flight. This was after a fresh restart of the simulator so that doesn't seem to be the issue. Sorry in advance for the zoomed in aspect as I haven't changed my resolution on my recording software for my new monitor. Finally, I mistakenly keep calling it an 'arrival' when it is an approach that I am selecting. I also just want to say that it's entirely possible that I am using the FMC incorrectly, leading to this crash. I'm not a trained pilot in the systems of the CRJ, only having flown it about 200 hours in the sim.