I'm using Prepar3d v4.2 and Windows 10 Professional (english version).
As I said, when preparing the aircraft on the ground, I do click on the pop-ups every once in a while and they work fine. I have to resize them as I'm using a triple monitor setup which means the dimensions are completely wrong, when popping them up for the first time (which is P3D/FSX problem and happens with all aircraft). However, after opening and closing them a couple of times, I get CTDs. Up to this point it only happened when popping up the PFD. It tried to use only the co-pilot's PFD on my last flight, but also got a CTD.
I have a very well maintained P3D as I would regard myself as a real power user who does have a deeper understanding of the inner workings, file structure, etc. of P3D. And I have various other add-ons (e.g. PMDG planes, FSL bus, Majestic Q400) where I don't have problems with CTDs when popping up the gauges.
Hope this helps.