In the aircraft.cfg this entry seems to have changed for the A321 IAE:
lift_scalar = 0.73
For the A321 CFM:
All of the A319-20 aircraft have this entry:
lift_scalar = 0.385 //0.86=>cfg 3
Just curious about the change - it seems odd that the A321 IAE would have a value so different from the rest.
For now it should work with 4.4 still. But we are always looking for ways to improve the product using the latest tools and therefore can only ensure the long term compatibility with the latest Prepar3D version.