Nein, ich hatte aber im Microsoft Flight Simulator Forum folgenden Tipp bekommen, der hilft:
In den Optionen unter Sounds bei Speech-to-Speech (oder so ähnlich) von "AZURE" auf "Windows offline" umschalten. Dann gibt es tatsächlich keine CTD's mehr (ich testete es mit dem Airbus A320neo).
With the help of srcooke and FlightsimSoft support I managed to solve the problem.
I post here the issue and how I solved it so it can be helpful for some other people.
When selected "Online source" as your weather source (by default is selected that way, at least in my case) you need a Server Subscription active. If you don't have an active subscription, the program will close after 3 seconds (the time it takes to PFPX to check your subscription status when you open the program).
The solution was to disable the Ethernet in my computer, open PFPX (now it won't be able to check the server subscription because the computer is offline) and then you go to Options and change the weather source (in my case I use Active Sky).
After that you can enable your Ethernet connection again, and the problem is gone.